Pharmacology Services

Our pharmacology team’s principal role is to support structure-activity relationships to advance the discovery programs. Our bioscience knowledge of target biology, therapeutic area specialization, and ability to work collaboratively at each stage of the drug discovery process allows the efficient design or transfer and validation of high-quality single assays or cascades to accelerate your hit finding, hit-to-lead and lead optimization programs. We have the expertise and infrastructure to support biochemical, cell-based and radio-ligand binding assays.

Biochemical Enzyme Assays

With an in-depth knowledge in enzymology, our team is capable of designing complex enzyme assays to study kinetic parameters. We have a broad toolbox of assay readouts that we will design or we can transfer and validate clients’ assays to support a fully integrated program.

Formats: homogenous and non-homogenous

Readouts:

  • Radiolabelled
  • Fluorescent
  • Colorimetric
  • Luminescent
  • Fluorescence polarization (FP)
  • Alpha screen
biochemical enzyme

Substrate identification and optimization Assay parameters :

  • Signal: background ratio (S/B)
  • Assay Linearity, substrate Km, Vmax
  • Turnover, reagent stability, pH, salt, detergent effect, reducer optimization, uniformity using multi-drop, etc.

Experience in broad classes of enzymes includes :

  • Inhibition assays: Determination IC50, Ki, Kd
  • Protein-protein interactions
  • We can support both 96 well and 384 well formats

radioisotope facility

Radio Isotope Facility

A dedicated Type-II radioactive facility is established to handle UNSEALED RADIOISOTOPES. The radioactive lab is provided to handle 3H, 32P, 14C, 35S. This facility works under the supervision of a dedicated Radiation safety officer (RSO). The facility was designed and constructed as per the AERB guidelines.

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